5ENN: The crystal structure of Human VPS34 in complex with a selective and potent inhibitor

PDB ID: 5ENNDownload
MMDB ID: 144919
PDB Deposition Date: 2015/11/9
Updated in MMDB: 2016/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5ENN: monomeric; determined by author and by software (PISA)
Molecular Components in 5ENN
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 3-kinase Catalytic Subunit Type 3
(Gene symbol: PIK3C3)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methyl-propan-2-ol1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methyl-propan-2-ol
2
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303