5EIR: Co-crystal structure of eIF4E with nucleotide mimetic inhibitor

PDB ID: 5EIRDownload
MMDB ID: 142782
PDB Deposition Date: 2015/10/30
Updated in MMDB: 2016/09
Experimental Method:
x-ray diffraction
Resolution: 2.69  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5EIR: dimeric; determined by author and by software (PISA)
Molecular Components in 5EIR
Label Count Molecule
Proteins (2 molecules)
1
Eukaryotic Translation Initiation Factor 4E
Molecule annotation
1
Eukaryotic Translation Initiation Factor 4 Gamma 1
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide
2
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303