5DGZ: Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

PDB ID: 5DGZDownload
MMDB ID: 133768
PDB Deposition Date: 2015/8/29
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.502  Å
Source Organism:
Similar Structures:
Biological Unit for 5DGZ: monomeric; determined by author and by software (PISA)
Molecular Components in 5DGZ
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Pim-1
(Gene symbol: PIM1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
2
2
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303