5DFC: Crystal structure of BRD2(BD2) W370F mutant with ligand I-BET 762 bound

PDB ID: 5DFCDownload
MMDB ID: 134135
PDB Deposition Date: 2015/8/26
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 5DFC: monomeric; determined by software (PISA)
Molecular Components in 5DFC
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 2
(Gene symbol: BRD2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
GLYCEROLGLYCEROL
2
1
NONAETHYLENE GLYCOLNONAETHYLENE GLYCOL
3
1
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
4
1
NICKEL (II) IONNICKEL (II) ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303