5DDE: Menin in complex with MI-859

PDB ID: 5DDEDownload
MMDB ID: 132555
PDB Deposition Date: 2015/8/24
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.78  Å
Source Organism:
Similar Structures:
Biological Unit for 5DDE: monomeric; determined by author and by software (PISA)
Molecular Components in 5DDE
Label Count Molecule
Protein (1 molecule)
1
Menin
(Gene symbol: MEN1)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
2
6-(2,2-difluoroethyl)-4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine6-(2,2-difluoroethyl)-4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine
2
4
SULFATE IONSULFATE ION
3
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
5
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303