5DB2: Menin in complex with MI-389

PDB ID: 5DB2Download
MMDB ID: 137865
PDB Deposition Date: 2015/8/20
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.54  Å
Source Organism:
Similar Structures:
Biological Unit for 5DB2: monomeric; determined by author and by software (PISA)
Molecular Components in 5DB2
Label Count Molecule
Protein (1 molecule)
1
Menin
(Gene symbol: MEN1)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
1
2-{2-cyano-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indol-1-yl}aceta mide2-{2-cyano-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indol-1-yl}aceta mide
2
3
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
4
5
SULFATE IONSULFATE ION
5
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303