5DB0: Menin in complex with MI-352

PDB ID: 5DB0Download
MMDB ID: 137863
PDB Deposition Date: 2015/8/20
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 5DB0: monomeric; determined by author and by software (PISA)
Molecular Components in 5DB0
Label Count Molecule
Protein (1 molecule)
1
Menin
(Gene symbol: MEN1)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
3
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
2
4
SULFATE IONSULFATE ION
3
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
1-[(2S)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1 H-indole-2-carbonitrile1-[(2S)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1 H-indole-2-carbonitrile
5
1
1-[(2R)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile1-[(2R)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303