5D75: Crystal Structure Of Human Fkbd25 In Complex With Fk506

Human FKBP25 (hFKBP25) is a nuclear immunophilin and interacts with several nuclear proteins, hence involving in many nuclear events. Similar to other FKBPs, FK506 binding domain (FKBD) of hFKBP25 also binds to immunosuppressive drugs such as rapamycin and FK506, albeit with a lower affinity for the latter. The molecular basis underlying this difference in affinity could not be addressed due to the lack of the crystal structure of hFKBD25 in complex with FK506. Here, we report the crystal structure of hFKBD25 in complex with FK506 determined at 1.8 A resolution and its comparison with the hFKBD25-rapamycin complex, bringing out the microheterogeneity in the mode of interaction of these drugs, which could possibly explain the lower affinity for FK506.
PDB ID: 5D75Download
MMDB ID: 138096
PDB Deposition Date: 2015/8/13
Updated in MMDB: 2016/04
Experimental Method:
x-ray diffraction
Resolution: 1.83  Å
Source Organism:
Similar Structures:
Biological Unit for 5D75: monomeric; determined by author
Molecular Components in 5D75
Label Count Molecule
Protein (1 molecule)
Peptidyl-prolyl Cis-trans Isomerase Fkbp3(Gene symbol: FKBP3)
Molecule annotation
Chemicals (3 molecules)
* Click molecule labels to explore molecular sequence information.

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