5CXV: Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium

PDB ID: 5CXVDownload
MMDB ID: 137246
PDB Deposition Date: 2015/7/29
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5CXV: dimeric; determined by author and by software (PISA)
Molecular Components in 5CXV
Label Count Molecule
Proteins (2 molecules)
1
Muscarinic Acetylcholine Receptor M1,endolysin,muscarinic Acetylcholine Receptor M1
Molecule annotation
1
Flag Peptide
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane
2
1
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
3
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
5
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303