5CRM: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

PDB ID: 5CRMDownload
MMDB ID: 135453
PDB Deposition Date: 2015/7/23
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 5CRM: monomeric; determined by author
Molecular Components in 5CRM
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
NITRATE IONNITRATE ION
2
1
N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamideN,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
3
1
GLYCEROLGLYCEROL
4
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303