5CGC: Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile

PDB ID: 5CGCDownload
MMDB ID: 131784
PDB Deposition Date: 2015/7/9
Updated in MMDB: 2015/12
Experimental Method:
x-ray diffraction
Resolution: 3.101  Å
Source Organism:
Similar Structures:
Biological Unit for 5CGC: monomeric; determined by author and by software (PISA)
Molecular Components in 5CGC
Label Count Molecule
Protein (1 molecule)
1
Metabotropic Glutamate Receptor 5,endolysin,metabotropic Glutamate Receptor 5
(Gene symbol: e)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
4
OLEIC ACIDOLEIC ACID
2
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
3
1
3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303