5C25: Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor

PDB ID: 5C25Download
MMDB ID: 131357
PDB Deposition Date: 2015/6/15
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.841  Å
Source Organism:
Similar Structures:
Biological Unit for 5C25: dimeric; determined by author and by software (PISA)
Molecular Components in 5C25
Label Count Molecule
Proteins (2 molecules)
1
Hiv-1 Reverse Transcriptase, P66 Subunit
Molecule annotation
1
Hiv-1 Reverse Transcriptase, P51 Subunit
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
6-({4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}amino)-5,7- dimethyl-2-naphthonitrile6-({4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}amino)-5,7- dimethyl-2-naphthonitrile
2
2
SULFATE IONSULFATE ION
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303