5C1X: Crystal Structure Of Ev71 3c Proteinase In Complex With Compound Viii

Citation:
Abstract
Enterovirus 71 (EV71) is the causative agent of hand, foot and mouth disease and can spread its infections to the central nervous and other systems with severe consequences. The replication of EV71 depends on its 3C proteinase (3Cpro ), a significant drug target. By X-ray crystallography and functional assays, the interactions between inhibitors and EV71 3Cpro were evaluated. It was shown that improved interactions at S4 for the substrate binding could significantly enhance the potency. A new series of potent inhibitors with high ligand efficiency was generated for developing antivirals to treat and control the EV71-associated diseases. Copyright (c) 2016 John Wiley & Sons, Ltd.
PDB ID: 5C1XDownload
MMDB ID: 139695
PDB Deposition Date: 2015/6/15
Updated in MMDB: 2016/10
Experimental Method:
x-ray diffraction
Resolution: 1.86  Å
Source Organism:
Similar Structures:
Biological Unit for 5C1X: monomeric; determined by author
Molecular Components in 5C1X
Label Count Molecule
Protein (1 molecule)
1
3C Proteinase
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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