5BWX: X-RAY CRYSTAL STRUCTURE AT 1.70A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A 4-CHLORO-2-FLUORO SUBSTITUTED PYRAZOLOPYRIMIDINONE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR

PDB ID: 5BWXDownload
MMDB ID: 130630
PDB Deposition Date: 2015/6/8
Updated in MMDB: 2015/07
Experimental Method:
x-ray diffraction
Resolution: 1.703  Å
Source Organism:
Similar Structures:
Biological Unit for 5BWX: dimeric; determined by software (PISA)
Molecular Components in 5BWX
Label Count Molecule
Proteins (2 molecules)
2
Branched-chain-amino-acid Aminotransferase, Mitochondrial
(Gene symbol: BCAT2)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
2
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
2
2
5-butyl-2-[(4-chloro-2-fluorobenzyl)amino]-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile5-butyl-2-[(4-chloro-2-fluorobenzyl)amino]-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
3
17
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
CHLORIDE IONCHLORIDE ION
5
2
GLYCEROLGLYCEROL
6
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303