5BQ0: Crystal Structure Of Bruton Agammaglobulinemia Tyrosine Kinase Complexed With Bms-824171 Aka 6-[(3r)-3-(4-tert-bu Tylbenzamido) Piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) Phenyl]amino}pyridine- 3-carboxamide

Citation:
Abstract
Four series of disubstituted carbazole-1-carboxamides were designed and synthesised as inhibitors of Bruton's tyrosine kinase (BTK). 4,7- and 4,6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of BTK, while 3,7- and 3,6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of Janus kinase 2 (JAK2).
PDB ID: 5BQ0Download
MMDB ID: 132918
PDB Deposition Date: 2015/5/28
Updated in MMDB: 2015/09
Experimental Method:
x-ray diffraction
Resolution: 1.57  Å
Source Organism:
Similar Structures:
Biological Unit for 5BQ0: monomeric; determined by author
Molecular Components in 5BQ0
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase BTK(Gene symbol: BTK)
Molecule annotation
Chemicals (4 molecules)
1
1
2
1
3
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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