5B6N: Crystal Structures Of Human Peroxiredoxin 6 In Sulfinic Acid State

Citation:
Abstract
Peroxiredoxins (Prxs) are a family of antioxidant enzymes found ubiquitously. Prxs function not only as H2O2 scavengers but also as highly sensitive H2O2 sensors and signal transducers. Since reactive oxygen species are involved in many cellular metabolic and signaling processes, Prxs play important roles in various diseases. Prxs can be hyperoxidized to the sulfinic acid (SO2H) or sulfonic acid (SO3H) forms in the presence of high concentrations of H2O2. It is known that oligomerization of Prx is changed accompanying oxidation states, and linked to the function. Among the six Prxs in mammals, Prx6 is the only 1-Cys Prx. It is found in all organs in humans, unlike some 2-Cys Prxs, and is present in all species from bacteria to humans. In addition, Prx6 has Ca(2+)-independent phospholipase A2 (PLA2) activity. Thus far only the crystal structure of Prx in the oxidized state has been reported. In this study, we present the crystal structures of human Prx6 in the reduced (SH) and the sulfinic acid (SO2H) forms.
PDB ID: 5B6NDownload
MMDB ID: 141105
PDB Deposition Date: 2016/5/30
Updated in MMDB: 2016/08
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 5B6N: dimeric; determined by author and by software (PISA)
Molecular Components in 5B6N
Label Count Molecule
Proteins (2 molecules)
2
Peroxiredoxin-6(Gene symbol: PRDX6)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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