5AX3: Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors

PDB ID: 5AX3Download
MMDB ID: 136379
PDB Deposition Date: 2015/7/14
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.984  Å
Source Organism:
Similar Structures:
Biological Unit for 5AX3: dimeric; determined by author and by software (PISA)
Molecular Components in 5AX3
Label Count Molecule
Proteins (2 molecules)
1
Mitogen-activated Protein Kinase 1
(Gene symbol: MAPK1)
Molecule annotation
1
Allosteric and Atp-competitive Inhibitor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303