5ANT: Potent and selective inhibitors of MTH1 probe its role in cancer cell survival

PDB ID: 5ANTDownload
MMDB ID: 136954
PDB Deposition Date: 2015/9/8
Updated in MMDB: 2017/09
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 5ANT: monomeric; determined by author and by software (PISA)
Molecular Components in 5ANT
Label Count Molecule
Protein (1 molecule)
1
7,8-dihydro-8-oxoguanine Triphosphatase
(Gene symbol: NUDT1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303