5AK0: Human PFKFB3 in complex with an indole inhibitor 6

PDB ID: 5AK0Download
MMDB ID: 128822
PDB Deposition Date: 2015/2/27
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 2.03  Å
Source Organism:
Similar Structures:
Biological Unit for 5AK0: dimeric; determined by author and by software (PISA)
Molecular Components in 5AK0
Label Count Molecule
Proteins (2 molecules)
2
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
(Gene symbol: PFKFB3)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
PHOSPHONIC ACIDPHOSPHONIC ACID
2
4
PHOSPHATE IONPHOSPHATE ION
3
2
6-O-phosphono-beta-D-fructofuranose6-O-phosphono-beta-D-fructofuranose
4
2
(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303