5AI8: Ligand Complex Structure Of Soluble Epoxide Hydrolase

Citation:
Abstract
Fragment-based drug discovery relies upon structural information for efficient compound progression, yet it is often challenging to generate structures with bound fragments. A summary of recent literature reveals that a wide repertoire of experimental procedures is employed to generate ligand-bound crystal structures successfully. We share in-house experience from setting up and executing fragment crystallography in a project that resulted in 55 complex structures. The ligands span five orders of magnitude in affinity and the resulting structures are made available to be of use, for example, for development of computational methods. Analysis of the results revealed that ligand properties such as potency, ligand efficiency (LE) and, to some degree, clogP influence the success of complex structure generation.
PDB ID: 5AI8Download
MMDB ID: 129318
PDB Deposition Date: 2015/2/12
Updated in MMDB: 2015/09
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 5AI8: dimeric; determined by author and by software (PISA)
Molecular Components in 5AI8
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Epoxide Hydrolase 2(Gene symbol: EPHX2)
Molecule annotation
Chemicals (10 molecules)
1
6
2
2
3
2
* Click molecule labels to explore molecular sequence information.

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