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5AHC:
Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
PDB ID:
5AHC
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MMDB ID:
129181
PDB Deposition Date:
2015/2/5
Updated in MMDB:
2024/05
Experimental Method:
x-ray diffraction
Resolution:
1.5 Å
Source Organism:
Human immunodeficiency virus type 1 (Z2/CDC-Z34 ISOLATE)
Similar Structures:
VAST+
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Biological Unit for 5AHC: dimeric; determined by author and by software (PISA)
Molecular Components in 5AHC
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Protease
Chemicals and Non-standard biopolymers (4 molecules)
1
3
CHLORIDE ION
2
1
(3R,3aS,4R,6aR)-4-[2-(methylamino)-2-oxoethoxy]hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303