5A8Y: Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

PDB ID: 5A8YDownload
MMDB ID: 141470
PDB Deposition Date: 2015/7/17
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 5A8Y: monomeric; determined by author and by software (PISA)
Molecular Components in 5A8Y
Label Count Molecule
Protein (1 molecule)
1
Neutrophil Elastase
(Gene symbol: ELANE)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
3
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
alpha-L-fucopyranosealpha-L-fucopyranose
3
1
METHYL {(7R)-6-CYANO-7-(4-CYANOPHENYL)-5-METHYL-4-[3-(TRIFLUOROMETHYL)PHENYL]-4,7-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL}CARBAMATEMETHYL {(7R)-6-CYANO-7-(4-CYANOPHENYL)-5-METHYL-4-[3-(TRIFLUOROMETHYL)PHENYL]-4,7-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL}CARBAMATE
4
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
5
1
MALONATE IONMALONATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303