5A8X: Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

PDB ID: 5A8XDownload
MMDB ID: 141469
PDB Deposition Date: 2015/7/17
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.23  Å
Source Organism:
Similar Structures:
Biological Unit for 5A8X: monomeric; determined by author and by software (PISA)
Molecular Components in 5A8X
Label Count Molecule
Protein (1 molecule)
1
Neutrophil Elastase
(Gene symbol: ELANE)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
3
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
alpha-L-fucopyranosealpha-L-fucopyranose
3
1
ethyl (5R)-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-1,5-dihydroimidazo[1,2-a]pyrimidin-4-ium-6-carboxylateethyl (5R)-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-1,5-dihydroimidazo[1,2-a]pyrimidin-4-ium-6-carboxylate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303