5A0C: Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

PDB ID: 5A0CDownload
MMDB ID: 131945
PDB Deposition Date: 2015/4/17
Updated in MMDB: 2015/08
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 5A0C: monomeric; determined by author and by software (PISA)
Molecular Components in 5A0C
Label Count Molecule
Protein (1 molecule)
1
Neutrophil Elastase
(Gene symbol: ELANE)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
2
ALPHA-L-FUCOSEALPHA-L-FUCOSE
3
2
(6S)-6-(4-cyano-2-methylsulfonyl-phenyl)-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carbonitrile(6S)-6-(4-cyano-2-methylsulfonyl-phenyl)-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carbonitrile
4
2
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
5
1
3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303