5A0B: Crystal Structure Of Human Neutrophil Elastase In Complex With A Dihydropyrimidone Inhibitor

PDB ID: 5A0BDownload
MMDB ID: 131944
PDB Deposition Date: 2015/4/17
Updated in MMDB: 2015/08
Experimental Method:
x-ray diffraction
Resolution: 2.23  Å
Source Organism:
Similar Structures:
Biological Unit for 5A0B: monomeric; determined by author and by software (PISA)
Molecular Components in 5A0B
Label Count Molecule
Protein (1 molecule)
1
Neutrophil Elastase
(Gene symbol: ELANE)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
3
N-Acetyl-D-GlucosamineN-Acetyl-D-Glucosamine
2
2
Alpha-L-FucoseAlpha-L-Fucose
3
1
(4r)-4-(4-Cyanophenyl)-6-Methyl-2-Oxidanylidene-3-[2-Oxidanylidene-2-(4-Propan-2-Ylpiperazin-1-Yl)ethyl]-1-[3-(Trifluoromethyl)phenyl]-4h-Pyrimidine-5-Carbonitrile(4r)-4-(4-Cyanophenyl)-6-Methyl-2-Oxidanylidene-3-[2-Oxidanylidene-2-(4-Propan-2-Ylpiperazin-1-Yl)ethyl]-1-[3-(Trifluoromethyl)phenyl]-4h-Pyrimidine-5-Carbonitrile
4
1
Dimethyl SulfoxideDimethyl Sulfoxide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303