5A00: Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor

PDB ID: 5A00Download
MMDB ID: 131744
PDB Deposition Date: 2015/4/15
Updated in MMDB: 2015/09
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 5A00: monomeric; determined by author and by software (PISA)
Molecular Components in 5A00
Label Count Molecule
Protein (1 molecule)
1
Poly [adp-ribose] Polymerase 1
(Gene symbol: PARP1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide
2
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303