4ZZI: SIRT1/Activator/Inhibitor Complex

PDB ID: 4ZZIDownload
MMDB ID: 131005
PDB Deposition Date: 2015/5/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.7346  Å
Source Organism:
Similar Structures:
Biological Unit for 4ZZI: dimeric; determined by author and by software (PISA)
Molecular Components in 4ZZI
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Protein Deacetylase Sirtuin-1
(Gene symbol: SIRT1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
(3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide(3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide
2
2
4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide
3
2
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303