4ZTJ: Crystal Structure of the Prototype Foamy Virus Intasome with a 2-Pyridinone Aminal Inhibitor

PDB ID: 4ZTJDownload
MMDB ID: 133987
PDB Deposition Date: 2015/5/14
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.67  Å
Source Organism:
Similar Structures:
Biological Unit for 4ZTJ: octameric; determined by author and by software (PISA)
Molecular Components in 4ZTJ
Label Count Molecule
Proteins (4 molecules)
4
PFV Integrase
Molecule annotation
Nucleotides(4 molecules)
2
DNA (5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp*cp*gp*cp*a)-3')
Molecule annotation
2
DNA (5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap*cp*a)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
2
ZINC IONZINC ION
2
8
GLYCEROLGLYCEROL
3
6
MAGNESIUM IONMAGNESIUM ION
4
6
SULFATE IONSULFATE ION
5
2
(1R,2S,5R)-8'-(3-chloro-4-fluorobenzyl)-6'-hydroxy-1-(hydroxymethyl)-2'-methyl-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione(1R,2S,5R)-8'-(3-chloro-4-fluorobenzyl)-6'-hydroxy-1-(hydroxymethyl)-2'-methyl-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303