4ZQP: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor MAD1

PDB ID: 4ZQPDownload
MMDB ID: 130186
PDB Deposition Date: 2015/5/10
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4ZQP: tetrameric; determined by author and by software (PISA)
Molecular Components in 4ZQP
Label Count Molecule
Proteins (4 molecules)
4
Inosine-5'-monophosphate Dehydrogenase,inosine-5'-monophosphate Dehydrogenase
(Gene symbol: guaB2)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
4
INOSINIC ACIDINOSINIC ACID
2
4
5'-O-({1-[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]-1H-1,2,3-triazol-4-yl}methyl)adenosine5'-O-({1-[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]-1H-1,2,3-triazol-4-yl}methyl)adenosine
3
4
POTASSIUM IONPOTASSIUM ION
4
4
PHOSPHATE IONPHOSPHATE ION
5
4
GLYCEROLGLYCEROL
6
4
S-1,2-PROPANEDIOLS-1,2-PROPANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303