4ZKL: Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)

Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine triad proteins superfamily. HINT1 plays an important role in various biological processes, and it has been found in many species. Here, we report the first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal. In addition, the apo form of hHINT1 at the space group P21 refined to 1.92A is reported for comparative studies.
PDB ID: 4ZKLDownload
MMDB ID: 136920
PDB Deposition Date: 2015/4/30
Updated in MMDB: 2018/03
Experimental Method:
x-ray diffraction
Resolution: 2.34  Å
Source Organism:
Similar Structures:
Biological Unit for 4ZKL: dimeric; determined by author and by software (PISA)
Molecular Components in 4ZKL
Label Count Molecule
Proteins (2 molecules)
Histidine Triad Nucleotide-binding Protein 1(Gene symbol: HINT1)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB