4ZHX: Novel binding site for allosteric activation of AMPK

PDB ID: 4ZHXDownload
MMDB ID: 236311
PDB Deposition Date: 2015/4/27
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.99  Å
Source Organism:
Similar Structures:
Biological Unit for 4ZHX: trimeric; determined by author and by software (PISA)
Molecular Components in 4ZHX
Label Count Molecule
Proteins (3 molecules)
1
5'-amp-activated Protein Kinase Catalytic Subunit Alpha-2
(Gene symbol: PRKAA2)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Beta-1
(Gene symbol: PRKAB1)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Gamma-1
(Gene symbol: PRKAG1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
(5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol(5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol
2
1
3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile
3
2
5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303