4ZHQ: Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex

PDB ID: 4ZHQDownload
MMDB ID: 141217
PDB Deposition Date: 2015/4/26
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.55  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 4ZHQ: hexameric; determined by author
Molecular Components in 4ZHQ
Label Count Molecule
Proteins (6 molecules)
2
Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
1
Tubulin-tyrosine Ligase
Molecule annotation
Chemicals and Non-standard biopolymers (23 molecules)
1
2
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
4
MAGNESIUM IONMAGNESIUM ION
3
3
CALCIUM IONCALCIUM ION
4
8
GLYCEROLGLYCEROL
5
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
6
2
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
7
1
N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamideN-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
8
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303