4Z55: Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378

PDB ID: 4Z55Download
MMDB ID: 136172
PDB Deposition Date: 2015/4/2
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Similar Structures:
Biological Unit for 4Z55: monomeric; determined by author and by software (PISA)
Molecular Components in 4Z55
Label Count Molecule
Protein (1 molecule)
1
ALK Tyrosine Kinase Receptor
(Gene symbol: ALK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
GLYCEROLGLYCEROL
2
1
N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamineN~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303