4Z3V: Fragment-Based Discovery of a Small Molecule Reversible Inhibitor of Bruton's Tyrosine Kinase

PDB ID: 4Z3VDownload
MMDB ID: 130573
PDB Deposition Date: 2015/3/31
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4Z3V: monomeric; determined by author and by software (PISA)
Molecular Components in 4Z3V
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase BTK
(Gene symbol: BTK)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
IMIDAZOLEIMIDAZOLE
2
1
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
4-amino-8-(5-methyl-1H-indazol-6-yl)cinnoline-3-carboxamide4-amino-8-(5-methyl-1H-indazol-6-yl)cinnoline-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303