4Z0L: The murine cyclooxygenase-2 complexed with a nido-dicarbaborate-containing indomethacin derivative

PDB ID: 4Z0LDownload
MMDB ID: 129982
PDB Deposition Date: 2015/3/26
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.29  Å
Source Organism:
Similar Structures:
Biological Unit for 4Z0L: dimeric; determined by author and by software (PISA)
Molecular Components in 4Z0L
Label Count Molecule
Proteins (2 molecules)
2
Prostaglandin G/H Synthase 2
(Gene symbol: Ptgs2)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
12
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
3
2
(R)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate(R)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate
4
2
(S)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate(S)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate
5
2
octyl beta-D-glucopyranosideoctyl beta-D-glucopyranoside
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303