4YX5: SpaO(SPOA1,2)

Citation:
Abstract
Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design.
PDB ID: 4YX5Download
MMDB ID: 129788
PDB Deposition Date: 2015/3/22
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.9001  Å
Source Organism:
Similar Structures:
Biological Unit for 4YX5: dimeric; determined by author and by software (PISA)
Molecular Components in 4YX5
Label Count Molecule
Proteins (2 molecules)
1
Surface Presentation of Antigens Protein Spao(Gene symbol: spaO)
Molecule annotation
1
Surface Presentation of Antigens Protein Spao(Gene symbol: spaO)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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