4YPS: (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB ID: 4YPSDownload
MMDB ID: 129784
PDB Deposition Date: 2015/3/13
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.1012  Å
Source Organism:
Similar Structures:
Biological Unit for 4YPS: monomeric; determined by author and by software (PISA)
Molecular Components in 4YPS
Label Count Molecule
Protein (1 molecule)
1
High Affinity Nerve Growth Factor Receptor
(Gene symbol: NTRK1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile
2
4
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303