4YMJ: (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB ID: 4YMJDownload
MMDB ID: 129782
PDB Deposition Date: 2015/3/6
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 4YMJ: monomeric; determined by author
Molecular Components in 4YMJ
Label Count Molecule
Protein (1 molecule)
1
Nt-3 Growth Factor Receptor
(Gene symbol: NTRK3)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
2
3
GLYCEROLGLYCEROL
3
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303