4YH2: Glutathione Transferase E6 From Drosophila Melanogaster

Epsilon class glutathione transferases (GSTs) have been shown to contribute significantly to insecticide resistance. We report a new Epsilon class protein crystal structure from Drosophila melanogaster for the glutathione transferase DmGSTE6. The structure reveals a novel Epsilon clasp motif that is conserved across hundreds of millions of years of evolution of the insect Diptera order. This histidine-serine motif lies in the subunit interface and appears to contribute to quaternary stability as well as directly connecting the two glutathiones in the active sites of this dimeric enzyme.
PDB ID: 4YH2Download
MMDB ID: 136359
PDB Deposition Date: 2015/2/26
Updated in MMDB: 2016/02
Experimental Method:
x-ray diffraction
Resolution: 1.72  Å
Source Organism:
Similar Structures:
Biological Unit for 4YH2: dimeric; determined by author and by software (PISA)
Molecular Components in 4YH2
Label Count Molecule
Proteins (2 molecules)
Glutathione S Transferase E6
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB