4YC8: C-Helix-Out Binding of Dasatinib Analog to c-Abl Kinase

PDB ID: 4YC8Download
MMDB ID: 136886
PDB Deposition Date: 2015/2/19
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4YC8: monomeric; determined by author and by software (PISA)
Molecular Components in 4YC8
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Abl1
(Gene symbol: ABL1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide
2
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303