4Y95: Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop

PDB ID: 4Y95Download
MMDB ID: 127967
PDB Deposition Date: 2015/2/16
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 1.599  Å
Source Organism:
Similar Structures:
Biological Unit for 4Y95: monomeric; determined by author and by software (PISA)
Molecular Components in 4Y95
Label Count Molecule
Protein (1 molecule)
1
Non-specific Protein-tyrosine Kinase
(Gene symbol: BTK)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide
2
1
GLYCEROLGLYCEROL
3
1
BETA-MERCAPTOETHANOLBETA-MERCAPTOETHANOL
4
1
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303