4Y86: Crystal structure of PDE9 in complex with racemic inhibitor C33

PDB ID: 4Y86Download
MMDB ID: 132624
PDB Deposition Date: 2015/2/16
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.01  Å
Source Organism:
Similar Structures:
Biological Unit for 4Y86: dimeric; determined by author
Molecular Components in 4Y86
Label Count Molecule
Proteins (2 molecules)
2
High Affinity Cgmp-specific 3',5'-cyclic Phosphodiesterase 9A
(Gene symbol: PDE9A)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
2
2
ZINC IONZINC ION
3
2
MAGNESIUM IONMAGNESIUM ION
4
1
6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303