4Y2E: Crystal Structure Of The Catalytic Domain Of Human Dual-specificity Phosphatase 7 (c232s)

Citation:
Abstract
Human dual-specificity phosphatase 7 (DUSP7/Pyst2) is a 320-residue protein that belongs to the mitogen-activated protein kinase phosphatase (MKP) subfamily of dual-specificity phosphatases. Although its precise biological function is still not fully understood, previous reports have demonstrated that DUSP7 is overexpressed in myeloid leukemia and other malignancies. Therefore, there is interest in developing DUSP7 inhibitors as potential therapeutic agents, especially for cancer. Here, the purification, crystallization and structure determination of the catalytic domain of DUSP7 (Ser141-Ser289/C232S) at 1.67 A resolution are reported. The structure described here provides a starting point for structure-assisted inhibitor-design efforts and adds to the growing knowledge base of three-dimensional structures of the dual-specificity phosphatase family.
PDB ID: 4Y2EDownload
MMDB ID: 129765
PDB Deposition Date: 2015/2/9
Updated in MMDB: 2015/06
Experimental Method:
x-ray diffraction
Resolution: 1.67  Å
Source Organism:
Similar Structures:
Biological Unit for 4Y2E: monomeric; determined by author and by software (PISA)
Molecular Components in 4Y2E
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Protein Phosphatase 7(Gene symbol: DUSP7)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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