4Y07: Crystal Structure Of The Hect Domain Of Human Wwp2

Acta Crystallogr F Struct Biol Commun (2015) 71 p.1251-1257
WWP2 is a HECT-domain ubiquitin ligase of the Nedd4 family, which is involved in various important biological processes, such as protein degradation, membrane-protein sorting and transportation, the immune response, pluripotency of embryonic stem cells, tumourigenesis and metastasis. The HECT domain provides the intrinsic ubiquitin ligase activity of WWP2. Here, the expression, purification, crystallization and crystallographic analysis of the HECT domain of human WWP2 (HECT(WWP2)) are reported. HECT(WWP2) has been crystallized and the crystals diffracted to 2.50 A resolution. They belonged to space group P41212 and the structure has been solved via molecular replacement. The overall structure of HECT(WWP2) has an inverted T-shape. This structure displays a high degree of conservation with previously published structures of Nedd4 subfamily members.
PDB ID: 4Y07Download
MMDB ID: 133870
PDB Deposition Date: 2015/2/5
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.51  Å
Source Organism:
Similar Structures:
Biological Unit for 4Y07: monomeric; determined by author
Molecular Components in 4Y07
Label Count Molecule
Protein (1 molecule)
Nedd4-like E3 Ubiquitin-protein Ligase Wwp2(Gene symbol: WWP2)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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