4XV3: B-Raf Kinase V600E oncogenic mutant in complex with PLX7922

PDB ID: 4XV3Download
MMDB ID: 133649
PDB Deposition Date: 2015/1/26
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 4XV3: dimeric; determined by author
Molecular Components in 4XV3
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamideN'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303