4XUF: Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

PDB ID: 4XUFDownload
MMDB ID: 128659
PDB Deposition Date: 2015/1/25
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 4XUF: monomeric; determined by author and by software (PISA)
Molecular Components in 4XUF
Label Count Molecule
Protein (1 molecule)
1
Receptor-type Tyrosine-protein Kinase Flt3
(Gene symbol: FLT3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303