4XT2: Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist

PDB ID: 4XT2Download
MMDB ID: 134665
PDB Deposition Date: 2015/1/22
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.698  Å
Source Organism:
Similar Structures:
Biological Unit for 4XT2: dimeric; determined by author and by software (PISA)
Molecular Components in 4XT2
Label Count Molecule
Proteins (2 molecules)
1
Aryl Hydrocarbon Receptor Nuclear Translocator
(Gene symbol: ARNT)
Molecule annotation
1
Endothelial PAS Domain-containing Protein 1
(Gene symbol: EPAS1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine(5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303