4XJP: Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead

PDB ID: 4XJPDownload
MMDB ID: 135652
PDB Deposition Date: 2015
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4XJP: dimeric; determined by author and by software (PISA)
Molecular Components in 4XJP
Label Count Molecule
Proteins (2 molecules)
2
Adenosylmethionine-8-amino-7-oxononanoate Aminotransferase
(Gene symbol: bioA)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
2
2
1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone
3
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303