4X7H: Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor

Citation:
Abstract
The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent, highly selective, and orally active tool compound suitable for PERK pathway biology exploration both in vitro and in vivo.
PDB ID: 4X7HDownload
MMDB ID: 126767
PDB Deposition Date: 2014/12/9
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 4X7H: monomeric; determined by author and by software (PISA)
Molecular Components in 4X7H
Label Count Molecule
Protein (1 molecule)
1
Eukaryotic Translation Initiation Factor 2-alpha Kinase 3,eukaryotic Translation Initiation Factor 2-alpha Kinase 3(Gene symbol: EIF2AK3)
Molecule annotation
Chemicals (3 molecules)
1
1
2
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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