4X3R: Avi-gcpii Structure In Complex With Fitc-conjugated Gcpii-specific Inhibitor

Citation:
Abstract
We present here a structure-aided design of inhibitors targeting the active site as well as exosites of glutamate carboxypeptidase II (GCPII), a prostate cancer marker, preparing potent and selective inhibitors that are more than 1000-fold more active toward GCPII than its closest human homologue, glutamate carboxypeptidase III (GCPIII). Additionally, we demonstrate that the prepared inhibitor conjugate can be used for sensitive and selective imaging of GCPII in mammalian cells.
PDB ID: 4X3RDownload
MMDB ID: 133247
PDB Deposition Date: 2014/12/1
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 1.86  Å
Source Organism:
Similar Structures:
Biological Unit for 4X3R: dimeric; determined by author and by software (PISA)
Molecular Components in 4X3R
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Carboxypeptidase 2(Gene symbol: FOLH1)
Molecule annotation
Chemicals (32 molecules)
1
4
2
2
3
2
4
20
5
2
6
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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